Catalysing multidisciplinary and multi-thematic approaches for patients.
From systems biology to new integrated and targeted healthcare solutions
While research has made great progresses to reveal complexity of biology, it has also introduced new convergence points between disciplines, approaches and areas of application. Seemingly dissimilar diseases are connected by significant unifying principles (signalling pathways, escape mechanisms from immune responses, etc.), some of them share elements of the same therapeutic approaches (vaccines, immunomodulators, etc.) others (diabetes, allergies, etc.) are associated with the same type of anomalies (dysbiosis) and, finally, all of these diseases are explored using new systems biology tools. By catalysing multidirectional exchanges between technological programmes and units, the Translational Science Programme is facilitating the use of this new "tool box". BIOASTER intends to use this global perspective to reveal new biomarkers as well as to innovate in the field of new integrated and targeted health solutions.
In this context, the mission of the Translational Science Programme (TSP) is to promote innovative projects by facilitating links between basic research and clinical research for the benefit of patients. Through innovative approaches, TSP's promotes the emergence of technologies related to personalized and predictive medicine. Current projects of the programme are undertaken in collaboration with multidisciplinary and multi-thematic partners (vaccines, diagnosis, microbiota and antimicrobials).
The TSP is part of a pre-competitive scope and encompasses research into biomarkers, the detection of and susceptibility to infectious diseases, multiparameter analysis of host-pathogen-microbiota interactions or even the identification of preclinical tools for screening new therapeutic stategies.
This strategy is based on the use multi-omic analyses (immune-profiling and multi-omic data) in combination with integrated biomedical data. The TSP's missions also include strategic and scientific watch to propose innovative solutions through interdisciplinary approaches.
The Translational Science Programme facilitates the integration of biological data generated by technological units, identifies the points of convergence between projects, evaluates new opportunities for innovation and implements interdisciplinary projects at BIOASTER.
Increasing the capacity to generate and analyse data
While biology has already has biology has already entered the age of bib data, today's challenge is to generate, integrate and analyse metadata in order to ensure greater understanding of the molecular networks (genes, proteins, métabolites, etc.) that regulate physiological functions of living systems. In this context, the programme is bringing together BIOASTER technology units and other programmes by fostering internal R&D projects designed to leverage our integrated analytical skills. Through this strategy, BIOASTER and its parteners intends to reduce the turnaroud time required to discover and validate biomarkers.
- Mechanistic understanding of natural infections
- Identification of pre-clinical tools for the rapid screening of new therapeutic strategies
- Identification of molecular signatures and biomarkers to evaluate health status and infectious diseases progression
- Role of microbiota on vaccine/antibiotic efficacy
- Predictive biomarkers of drug and vaccine efficacy
- Personalized medicine against infectious diseases
- Multi-omics analysis (clinical, genomics, transcriptomics, proteomics and metabolomics)
- Multi parametric data analysis
- Multi system data integration