TECHNOLOGY UNIT : BIOLOGICAL MICROSYSTEMS & ADVANCED OPTICS ENGINEERING
Microfluidic systems implementation & optical characterization
At low dimension, the behaviour of fluids differs from that at macroscopic level. Indeed, reducing the dimensions allows the formation of a very predictable flow regime, in contrast to the chaotic behaviour of the turbulent flow that occurs at our scale. This enables easy manipulation of microscopic objects as well as reduction of reagent quantities, opening possibilities for a wide variety of applications in the fields of microbiology, medical diagnostics and chemical analysis. Moreover, any assay or diagnostic tool requires an automated readout technique. The smaller the size of the object to observe, the more sensitive and specific the readout technique must be. Nowadays, highly-sensitive and advanced optical microscopies and spectroscopies give access to morphological, structural and/or chemical information about biological cells, characterized in most cases by weak absorption and scattering of light.
Microfluidics and advanced Optics can be combined to perform accurate phenotype-based or functional-based characterization of biological microsystems.
Droplet-based microfluidics can also be associated to cell sorter technology to perform ultra-High-Throughput droplet sorting.
These associations offers powerful analysis advantages over more classical techniques:
These new technologies have emerged as a very potent tool in a wide range of applications, from life science to clinical research.