Publications:

2019

• Chagas Disease Drug Discovery: Multiparametric Lead Optimization against Trypanosoma cruzi in Acylaminobenzothiazole Series
  Authors: Charlotte Fleau, Angel Padilla, Juan Miguel-Siles, Maria T. Quesada-Campos, Isabel Saiz-Nicolas, Ignacio Cotillo, Juan Cantizani Perez, Rick L. Tarleton, Maria Marco and Gilles Courtemanche.
  J. Med. Chem. 2019, 62, 10362−10375
  https:// pubs.acs.org/jmc

• Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease
  Authors: Hennig K., Abi‑Ghanem J., Bunescu A., Meniche X., Biliaut E., Ouattara A. D., Lewis M. D., Kelly J. M., Braillard S., Courtemanche G., Chatelain E., Béquet F.
  Metabolomics (2019) 15:117 https://doi.org/10.1007/s11306-019-1583-5

• Evaluation of integrative clustering methods for the analysis of multi-omics data
  Authors: Chauvel C, Novoloaca A, Veyre P, Reynier F, Becker J
  Brief Bioinform. 2019 Feb 14. pii: bbz015. doi: 10.1093/bib/bbz015

• Early herpes and TTV DNAemia in septic shock patients: a pilot study
  Authors: Mallet F, Perret M, Tran T, Meunier B, Guichard A, Tabone O, Mommert M, Brengel-Pesce K, Venet F, Pachot A, Monneret G, Reynier F, Védrine C, Leinsser P, Mouscadel V, Lepape A, Textoris J, MIPrea Group, REALISM group
  Journal Intensive Care Med Exp. 2019

• Combination of ribosome display and next generation sequencing as a powerful method for identification of affibody binders against β-lactamase CTX-M15
  Authors: Lagoutte P, Lugari A, Elie C, Potisopon S, Donnat S, Mignon C, Mariano N, Troesch A, Werle B, Stadthagen G.;
  Journal: N Biotechnol. 2019 May 25;50:60-69
• Safety of AS03-adjuvanted influenza vaccines: A review of the evidence.
  Authors: Cohet C, van der Most R, Bauchau V, Bekkat-Berkani R, Doherty TM, Schuind A, Tavares Da Silva F, Rappuoli R, Garçon N, Innis BL. Vaccine. 2019
• Polymorphisms of a Collagen-Like Adhesin Contributes to Legionella pneumophila Adhesion, Biofilm Formation Capacity and Clinical Prevalence.
  Authors: Abdel-Nour M, Su H, Duncan C, Li S, Raju D, Shamoun F, Valton M, Ginevra C, Jarraud S, Guyard C, Kerman K, Terebiznik MR. Front Microbiol. 2019.

2018

• Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis
  Authors: Voegele A, O’Brien DP, Subrini O, Sapay N, Cannella SE, Enguéné VYN, Hessel A, Karst J, Hourdel V, Perez ACS, Davi M, Veneziano R, Chopineau J, Vachette P, Durand D, Brier S, Ladant D, Chenal A.
  Journal: Pathog Dis.
• Metagenomics next generation sequencing reveals individual composition and dynamics of anelloviruses during autologous stem cell Transplant Recipient Management
  Authors: Bal A, Sarkozy C, Josset L, Cheynet V, Oriol G, Becker J, Vilchez G, Sesques P, Mallet F, Pachot A, Morfin F, Lina B, Salles G, Reynier F, Trouillet-Assant S, Brengel-Pesce K.
  Journal: Viruses
• Simultaneous surface display and cargo loading of encapsulin nanocompartments and their use for rational vaccine design
  Authors: Lagoutte P, Mignon C, Stadthagen G, Potisopon S, Donnat S, Mast J, Lugari A, Werle B.
  Journal: Vaccine
• A steam-based method to investigate biofilm
  Authors: Tasse J, Cara A, Saglio M, Villet R, Laurent F.
  Journal: Sci Rep.
• Biosensors for the Detection of Interaction between Legionella pneumophila Collagen-Like Protein and Glycosaminoglycans
  Authors: Su H, Li S, Terebiznik M, Guyard C, Kerman K.
  Journal: Sensors (Basel).
• A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection
  Authors: Singhania A, Verma R, Graham CM, Lee J, Tran T, Richardson M, Lecine P, Leissner P, Berry MPR, Wilkinson RJ, Kaiser K, Rodrigue M, Woltmann G, Haldar P, O’Garra A.
  Journal: Nat Commun.
• Small Rho GTPases and the Effector VipA Mediate the Invasion of Epithelial Cells by Filamentous Legionella pneumophila
  Authors: Prashar A, Ortiz ME, Lucarelli S, Barker E, Tabatabeiyazdi Z, Shamoun F, Raju D, Antonescu C, Guyard C, Terebiznik MR.
  Journal: Front Cell Infect Microbiol.
• Culture-free Antibiotic-susceptibility Determination From Single-bacterium Raman Spectra
  Authors: Novelli-Rousseau A, Espagnon I, Filiputti D, Gal O, Douet A, Mallard F, Josso Q.
  Journal: Sci Rep.
• Codon harmonization – going beyond the speed limit for protein expression
  Authors: Mignon C, Mariano N, Stadthagen G, Lugari A, Lagoutte P, Donnat S, Chenavas S, Perot C, Sodoyer R, Werle B.
  Journal: FEBS Press
• Lactobacillus paracasei feeding improves the control of secondary experimental meningococcal infection in flu-infected mice
  Authors: Belkacem N, Bourdet-Sicard R, Taha MK.
  Journal: BMC Infect Dis.

2017

• The human gut microbiome as source of innovation for health: Which physiological and therapeutic outcomes could we expect?
  Authors: Doré J, Multon MC, Béhier JM, Affagard H, Andremont A, Barthélémy P, Batitsa R, Bonneville M, Bonny C, Boyaval G, Chamaillard M, Chevalier MP, Cordaillat-Simmons M, Cournarie F, Diaz I, Guillaume E, Guyard C, Jouvin-Marche E, Martin FP, Petiteau D.
  Review: Therapie, Elsevier
• Modulation of estrogen related receptor alpha activity by the kinesin KIF17.
  Authors: Seneviratne APB, Turan Z, Hermant A, Lecine P, Smith WO, Borg JP, Jaulin F, Kreitzer G.
  Journal: Oncotarget
• Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region
  Authors: Voegele A, Subrini O, Sapay N, Ladant D, Chenal A.
  Journal: Toxins (Basel).
• Lactobacillus paracasei feeding improves immune control of influenza infection in mice
  Authors: Belkacem N, Serafini N, Wheeler R, Derrien M, Boucinha L, Couesnon A, Cerf-Bensussan N, Gomperts Boneca I, Di Santo JP, Taha MK, Bourdet-Sicard R.
  Journal: PLoS One.
• Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits
  Authors: Delannois F, Planty C, Giordano G, Destexhe E, Stanislaus D, Da Silva FT, Stegmann JU, Thacker K, Reynaud L, Garçon N, Segal L.
  Journal: Reprod Toxicol.
• Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
  Authors: Coccia M, Collignon C, Hervé C, Chalon A, Welsby I, Detienne S, Helden MJV, Dutta S, Genito CJ, Waters NC, Deun KV, Smilde AK, Berg RAVD, Franco D, Bourguignon P, Morel S, Garçon N, Lambrecht BN, Goriely S, Most RV, Didierlaurent AM.
  Journal: NPJ Vaccines
• Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans
  Authors: Burny W, Callegaro A, Bechtold V, Clement F, Delhaye S, Fissette L, Janssens M, Leroux-Roels G, Marchant A, van den Berg R. A, Garçon N, van der Most R and Didierlaurent Arnaud M. On Behalf of the ECR-002 Study Group
  Journal: Frontiers in Immunology
• The REAnimation Low Immune Status Markers (REALISM) project: a protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients
  Authors: Rol ML, Venet F, Rimmele T, Moucadel V, Cortez P, Quemeneur L, Gardiner D, Griffiths A, Pachot A, Textoris J, Monneret G; REALISM study group.
  Journal: BMJ Open
• Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre- and post-natal development in Sprague-Dawley rats
  Authors: Segal L, Thacker K, Fochesato M, Giordano G, Garçon N, Destexhe E.
  Journal: Reprod Toxicol.
• Type I interferon-mediated autoinflammation due to DNase II deficiency
  Authors: Rodero M.P , Tesser A, Bartok E, Rice G. I. , Della Mina E , Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, Dussiot M, Frémond M-L, Gattorno M, Guillem F, Kitabayashi N, Porcheray F, Rieux-Laucat F, Seabra L, Uggenti C, Volpi S, Zeef L.A.H , Alyanakian M-A, Beltrand J, Bianco A-M, Boddaert N, Brouzes C, Candon S, Caorsi R, Charbit M, Fabre M, Faletra F, Girard M, Harroche A, Hartmann E, Lasne D, Marcuzzi A, Neven B, Nitschke P, Pascreau T, Pastore S, Picard C, Picco P,Piscianz E, Polak M, Quartier P, Rabant M, Stocco G, Taddio A, Uettwiller F, Valencic E, Vozzi D, Hartmann G, Barchet W, Hermine O, Bader-Meunier B, Tommasini A & Crow Y.J
  Journal: Nature Communication
• Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity
  Authors: Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain P-O, Schandene L, Casartelli N, Rameix-Welti M-A, Herve P-L , Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët J-F et Riffault S , Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P and Lo-Man R.
  Journal: Immunity
• Adjuvant system AS01: helping to overcome the challenges of modern vaccines
  Authors: Didierlaurent AM, Laupèze B, Di Pasquale A, Hergli N, Collignon C, Garçon N.
  Journal: Expert Rev Vaccines
• From discovery to licensure, the Adjuvant System story
  Authors: Garçon N, Di Pasquale A.
  Journal: Hum Vaccin Immunother
• Non-conventional expression systems for the production of vaccine proteins and immunotherapeutic molecules
  Authors: Legastelois I, Buffin S, Peubez I, Mignon C, Sodoyer R,Werle B
  Review: Hum Vaccin & immunotherapeutics
• Microbiote intestinal : qu’en attendre au plan physiologique et thérapeutique ?
  Authors: Doré J, Multon MC, Béhier JM; les participants à la table ronde 2 des Ateliers de Giens XXXII, Affagard H, Andremont A, Barthélémy P, Batista R, Bonneville M, Bonny C, Boyaval G, Chamaillard M, Chevalier MP, Cordaillat-Simmons M, Cournarie F, Diaz I, Guillaume E, Guyard C, Jouvin-Marche E, Martin FP, Petiteau D.
  Journal: Therapie
• Clinical, virological, and biological parameters associated with outcomes of Ebola virus infection in Macenta, Guinea
  Authors: Vernet MA, Reynard S, Fizet A, Schaeffer J, Pannetier D, Guedj J, Rives M, Georges N, Garcia-Bonnet N, Sylla AI, Grovogui P, Kerherve JY, Savio C, Savio-Coste S, de Séverac ML, Zloczewski P, Linares S, Harouna S, Abdoul BM, Petitjean F, Samake N, Shepherd S, Kinda M, Koundouno FR, Joxe L, Mateo M, Lecine P, Page A, Tchamdja TM, Schoenhals M, Barbe S, Simon B, Tran-Minh T, Longuet C, L’Hériteau F, Baize S.
  Journal: JCI Insight Cedratvirus lausannensis – digging into Pithoviridae diversity
  Authors: Bertelli C, Mueller L, Thomas V, Pillonel T, Jacquier N, Greub G.
• Cedratvirus lausannensis – digging into Pithoviridae diversity.
  Bertelli C, Mueller L, Thomas V, Pillonel T, Jacquier N, Greub G.
  Environ Microbiol.

2016

• SNP calling from RNA-seq data without a reference genome: identification, quantification, differential analysis and impact on the protein sequence
  Authors: Lopez-Maestre H, Brinza L, Marchet C, Kielbassa J, Bastien S, Boutigny M, Monnin D, Filali AE, Carareto CM, Vieira C, Picard F, Kremer N, Vavre F, Sagot MF, Lacroix V.
  Journal: Nucleic Acids Res.
• Chapitre: Les vaccins ou deux siècles de biotechnologies
  Authors: Sodoyer R, Drouet E, Werle B
  Book: Les biotechnologies en santé tome1.
• From discovery to licensure, the Adjuvant System story
  Authors: Garçon N, Di Pasquale A.
  Journal: Hum Vaccin Immunother.
• Vaccine safety evaluation: Practical aspects in assessing benefits and risks
  Authors: Di Pasquale A, Bonanni P, Garçon N, Stanberry LR, El-Hodhod M, Tavares Da Silva F.
  Journal: Vaccine
• Vaccine provision: Delivering sustained & widespread use
  Authors: Preiss S, Garçon N, Cunningham AL, Strugnell R, Friedland LR.
  Journal: Vaccine
• Vaccine development: From concept to early clinical testing
  Authors: Cunningham AL, Garçon N, Leo O, Friedland LR, Strugnell R, Laupèze B, Doherty M, Stern P.
  Journal: Vaccine
• Zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an FDA-approved library
  Authors: Pascoalino B.S, Courtemanche G, Cordeiro M.T, Gil L. H. V. G. , Freitas-Junior L
  Journal: F1000Research
• Impact of adjuvants on CD4(+) T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial
  Authors: Leroux-Roels G, Marchant A, Levy J, Van Damme P, Schwarz TF, Horsmans Y, Jilg W, Kremsner PG, Haelterman E, Clément F, Gabor JJ, Esen M, Hens A, Carletti I, Fissette L, Tavares Da Silva F, Burny W, Janssens M, Moris P, Didierlaurent AM, Van Der Most R, Garçon N, Van Belle P, Van Mechelen M.
  Journal: Clin Immunol.
• Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor
  Authors: Gresnigt M.S. , Rekiki A, Rasid O, Savers A, Jouvion G, Dannaoui E, Parlato M, Fitting C, Brock M, Cavaillon J-M, van de Veerdonk F. L. & Ibrahim-Granet O
  Journal: Nature Scientific Reports
• Chapter 5: Hydrophilic Interaction Liquid Chromatography (HILIC) and Perfluorinated Stationary Phases, pp. 149-184
  Authors: Cristina C. JACOB
  Book: Fast Liquid Chromatography – Mass Spectrometry Methods in Food and Environmental Analysis (Imperial College Press)
• Legionella CRISPR-Cas reveals a recurrent challenge to the pathogen
  Authors: Rao C, Guyard C, Pelaz C, Wasserscheid J, Bondy-Denomy J, Dewar K, Ensminger AW.
  Journal: Cell Microbiol.
• Scalable chromatography-based purification of virus-like particle carrier for epitope based Influenza A vaccine produced in Escherichia coli
  Authors: Lagoutte P, Mignon C, Donnat S, Stadthagen G, Mast J, Sodoyer R, Lugari A and Werle B
  Journal: J. Virol. Methods
• Non-clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys
  Authors: Garçon N, Silvano J, Kuper CF, Baudson N, Gérard C, Forster R, Segal L.
  Journal: J Appl Toxicol.

2015

• Differential proteomic analysis of virus-enriched fractions obtained from plasma pools of patients with dengue fever or severe dengue
  Authors: Fragnoud R, Flamand M, Reynier F, Buchy P, Duong V, Pachot A, Paranhos-Baccala G, Bedin F.
  Journal: BMC Infect Dis.
• Draft Genome Sequences of Acinetobacter parvus CM11, Acinetobacter radioresistens CM38, and Stenotrophomonas maltophilia BR12, Isolated from Murine Proximal Colonic Tissue
  Authors: Saffarian A, Mulet C, Naito T, Bouchier C, Tichit M, Ma L, Grompone G, Sansonetti PJ, Pédron T.
  Journal: Genome Announc.
• Vaccine Adjuvants: from 1920 to 2015 and Beyond
  Authors: Di Pasquale A, Preiss S, Tavares Da Silva F, Garçon N.
  Journal: Vaccines
• Antibiotic free selection in Biotherapeutics
  Authors: Mignon C. , Sodoyer R. , Werle B.
  Journal: Antibiotic free selection in Biotherapeutics: Now and Forever, Pathogens
• A FACS-optimized screen identifies regulators of genome stability in Candida albicans
  Authors: Loll-Krippleber R, Feri A, Nguyen M, Maufrais C, Yansouni J, d’Enfert C, Legrand M
  Journal: Eukaryot Cell.
• Non clinical reproductive and developmental safety evaluation of he MAGE-A3 Cancer Immunotherapeutic, a therapeutic vaccine for cancer treatment
  Authors: Destexhe E, Stannard D, Wilby OK, Grosdidier E, Baudson N, Forster R, Gérard CM, Garçon N, Segal L.
  Journal: Elsevier, Reproductive toxicology Volume 51