Technology unit
Preclinical Models & Imaging

Provides you innovative animal models/technologies in infectious diseases & microbiota

Technology unit Preclinical Models & Imaging

Provides you innovative animal models/technologies in infectious diseases & microbiota

Animal models represent important and invaluable tools both to study the pathogenesis of infectious diseases, and to decipher host/pathogen interactions. Those animal models allow to perform preclinical evaluation of vaccines and therapies against a wide variety of human pathogens, as well as assess probiotics intended to provide a specific clinical health benefit in humans.

The need for predictive preclinical animal models in emerging or re-emerging infectious diseases is more than ever critical.

Our purpose is to allow you to identify the most pertinent animal model & relevant read outs to answer the biological question asked and obtain information translatable to humans. Identically, we help you to investigate microbiota impacton animal models and translate this knowledge to human situations.

Exploitation of Multi-modality small animal imaging for longitudinal monitoring of real time in life events

We design and implement longitudinal studies for the monitoring of infection and/or inflammatory diseases to detect developments or changes in the characteristics of the target population at both the group and the individual level.
We provide imaging modalities such as bioluminescence or fluorescence (multimodality imaging) to generate quantitative and functional measurements during an infection such as localization, extension, metabolic activity, immunological response, inflammation, drug concentration and biodistribution. The integration and co-registration with imaging anatomical techniques (e.g. microtomography) provides integrated data on molecular and anatomical features of the infection.

I would like to know more on longitudinal
studies design and implementation

Development & customization of translational pre-clinical models dedicated to infectious diseases

The preclinical models & imaging unit develops and deploys predictive animal models, in vivo assays and imaging techniques to advance and refine studies. It also evaluate within those models, the mechanism of action, pharmacological properties and efficacy of therapeutic and prophylactic treatments against infectious diseases.

We can provide you with models for microbial infections, classical (antimicrobials, vaccines) or alternative emerging therapies (natural products/extracts, phage therapy, …).

We can help you with the identification and sourcing of clinically relevant isolates, characterization of bacterial strains (antibiotic resistance, MIC, growth kinetics, viral or bacterial titration) and implementation of selected microbial or viral pathogens in the most suitable animal model according to your needs and biological question.

In vivo imaging technologies are routinely performed to facilitate the non-invasive longitudinal monitoring of disease progression, cell trafficking, inflammation and gene expression patterns in living animals.

You seek to develop a specific on demand models?
Contact us for more information and to discuss your needs.

Development of pre-clinical models to assess the impact of microbiota on health and disease

We exploit the potency of gnotobiology (the study of animals raised in environments free of micro-organisms or those which contain only specifically known micro-organisms) in order to understand the role of gut microbiota in areas such as inflammatory, metabolic, immune or neurobehavioral diseases.

We help you evaluate the impact of microbiota in the advancement of new therapies to fight infectious diseases or in the development of pre/probiotics, and to understand the impact of microbiota in health and disease in areas such as infectious, inflammatory, metabolic, immune or neurobehavioral diseases.

We provide you with predictive pre-clinical models combining emerging technologies in imaging analysis, functional genomics, metabolomics, immunology and molecular biology to study the complex interaction between the microbe(s) and the host.

You want to know more?

small animal imaging: avantages / added values

Noninvasive
Measurements of
molecular pathways
Allows for longitudinal monitoring
Each animal can be followed over the whole course of infection
Animal Welfare:
In accordance with 3Rs
(Refinement, Reduction, Replacement)
Multimodality
Imaging could simuttaneously visualize several different processes
(bacterial burden, antibiotic, exposure, inflammation)
Allow integration of cross-species data
From animals to humans
(PET, SCPECT, IRM…)
Structural imaging
(in combination with CT):
Provide an anatomic reference

Deploying imaging techniques to explore Host-microbes interaction

We provide you with advanced histopathological techniques to explore host-microbes interactions, including immunohistology and fluorescence in situ hybridization (FISH) with the ability to identify specific molecules and structures, intra or extracellular, as well as microbes in complex microbial organizations such as the intestinal ecosystem. The combination of microbial markings and immunomarkings of the host response makes it possible to highlight specific host-microbe interactions at a local level.

I would like to know more on longitudinal
studies design and implementation

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