BIOASTER and Institut Pasteur are proud to join forces to build a novel microphysiological system (MPS) mimicking the first steps of immune activation during vaccination. This system will enable studying vaccine mode of action by triggering the immune cell activation in a dynamic model using circulating immune cells. Such a system takes advantage of a dynamic environment with controllable physio-chemical conditions to develop a more predictive device as compared to existing static in vitro systems.
This MPS arises from a strong unmet need to develop innovative preclinical solutions using human cells to predict vaccine immunogenicity and mitigate the risk of preclinical vaccine development.
Our goal is to build a device that can be used to study existing and new vaccine technologies such as mRNA and novel adjuvants and ultimately decrease the need for animal models.