Technological developments

Omics & BioAnalyics

Cell biology

Advanced optical system applied to biology

Perform both custom & industrialized data analysis & integration

Build digital solutions to smooth data analytics & exploration progress

Bioprocessing

Technological developments

Technological developments

Developing more targeted, effective and personalized health solutions now requires technology to become an integral part of your R&D program or of your clients and partners R&D programs.

As a health product development company, a solution provider, a CRO or a CDMO, you seek for partners to help you to reimagine the technologies to integrate in your solutions, your services or R&D process or extend your ecosystem of partners to disrupt your R&D, by applying emerging technologies.

As a Technology Research Institute, we integrate the engineering sciences by developing technological tools or systems in the fields of biology.

You benefit from a tightly integrated team of biologists, physicists and engineers capable of optimizing technology solutions with a very high degree of multi-disciplinary design complexity. Specialists will be brought together to address your questions and needs. This team will elaborate and implement a tailored project plan to ensure timely and efficient delivery of expected outcomes.

We cover all area of intervention in technology design and development, i.e.:

  • prototype, iterate and validate various aspects of a system, including biology and physics;
    Our case study: Multiway
  • co-develop prototypes by integrating partner technological building blocks;
  • evaluate new prototypes or technologies (due diligence, set-up specifications, recommendations, beta testing);
    Discover our case studies: Covert, AllTest
  • validate or extend the field of application of an existing technology.
    Learn more with our case studies: Codira 2, HeatStab, Covaris

We work at the intersection of physics, engineering, statistics and digital & biological sciences, creating and developing new life science technologies for your diagnostic/drug development or solution improvement, focusing on:

1

Omics & BioAnalyics

Omics are today in the heart of R&D and may need to be part of your technological development. Based on our expertise in omics technologies, we can help you validate your new instrumentation, tool or method, at all steps of the omics workflow, including sample preparation, bioanalysis or bioinformatics.

Likewise, if you need to validate your field of application or explore new ones, you will benefit from our SMART Omics strategy in the design and implementation of relevant omics protocols.

Discover more in our case studies: HeatStab, Covaris, InsightCell and Metagenomics.

To learn more about our Bioassays & Microsystems technology, click here.

2

Cell biology

Your R&D pipeline may require isolating, identifying and characterizing bacteria or pathogens, modeling biofilm, characterizing immune-host response, testing vaccines/drugs in vitro.

We can develop, build and apply organ-on-chip systems that better mimic the in-vivo cellular environment. Our microfluidic expertise and technology will be the cornerstone for adapting, developing, validating or implementing single cell technologies that enable rapid, reliable and deep characterization and isolation of cells.

3

Advanced optical system applied to biology

We can combine robust sample preparation with advanced optical methods in integrated systems. We successfully optimized Raman spectroscopy and Holographic microscopy in prototypes to image and monitor single bacteria changes (morphology, phase, Raman signature) over time.
These approaches could be applied to any biological questions you might have and would benefit from these advanced technologies.

You can learn more about our Bioassays & Microsystems technologie here.

4

Perform both custom & industrialized data analysis & integration

Most of life science technologies produce large volume of heterogeneous and complex data, from structured to unstructured ones (e.g. images).

We have designed our own catalog of bioinformatics methods capable to handle the best the main types of those data. These methods, once fully benchmarked against both simulated and real-world dataset, are pipelined and the resulting ready-to-run workflows offer cost-cut and reduced time-to-results perspectives for a direct application and benefit to your data.

Similar approaches address statistical & machine learning-centred data integration and translate your most complex questions in terms of MoA or signatures into biological outcomes.

Read our expertise in xDATA technoloy here.

5

Build digital solutions to smooth data analytics & exploration progress

Advanced algorithms and treatment pipelines originated from bioinformatics and data science may be embedded into digital solutions and appliance, which thus offer augmented user experience (UX) in terms of data tracking, task automations, results visualization and interpretation.

We apply the state-of-the-art core technologies of our software engineering platform running in DevOps context (e.g. Continuous Integration) to design, then implement, your custom Web-platforms addressing final issues in terms of decision-support/making or hypothesis making/validation.

Our proposal is to deliver an initial prototype (e.g. technical & functional specifications, data modeling, software development, tests & user acceptance) you will have to turn into a final in house or commercial product.

Learn about our xDATA technology here.

2

Cell biology

Your R&D pipeline may require isolating, identifying and characterizing bacteria or pathogens, modeling biofilm, characterizing immune-host response, testing vaccines/drugs in vitro.

We can develop, build and apply organ-on-chip systems that better mimic the in-vivo cellular environment. Our microfluidic expertise and technology will be the cornerstone for adapting, developing, validating or implementing single cell technologies that enable rapid, reliable and deep characterization and isolation of cells.

4

Perform both custom & industrialized data analysis & integration

Most of life science technologies produce large volume of heterogeneous and complex data, from structured to unstructured ones (e.g. images).

We have designed our own catalog of bioinformatics methods capable to handle the best the main types of those data. These methods, once fully benchmarked against both simulated and real-world dataset, are pipelined and the resulting ready-to-run workflows offer cost-cut and reduced time-to-results perspectives for a direct application and benefit to your data.

Similar approaches address statistical & machine learning-centred data integration and translate your most complex questions in terms of MoA or signatures into biological outcomes.

Read our expertise in xDATA technology here.

6

Bioprocessing

Bioproduction quality monitoring is often ensured by measurements of a limited number of standard variables (e.g. oxygen consumption, pH variation, or measurement of certain metabolites). To improve production yield or avoid yield loss, to design online and real-time quality control bioprocesses (such as proteins, monoclonal antibodies, as part of an autologous or heterologous cell therapy workflow), we develop your customized technologies for optimized and continuous control.

They are combining in-silico approaches based on digital twins allowing the simulation of metabolic processes during bioproduction, with the identification of biomarkers in optimal conditions or stress through the generation of longitudinal multi-omics data.

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